Assessing the value of novel molecular imaging techniques: multiparametric
MRI, nano-particle MRI, and 68Ga PSMA-PET/CT to predict local tumor grade and map lymph node metastasis in patients with prostate cancer scheduled for prostatectomy and lymph node dissection.
Aims and objectives:
To prospectively determine the clinical value and accuracy of
multi-parametric MRI (mp-MRI) and 68Ga PSMA-PET/CT for local tumor grade
nano-MRI (Combidex-MRI) plus
68Ga PSMA-PET/CT for the detection of lymph node metastases
in patients with prostate cancer and intermediate
to high risk for lymph node metastases (>15% according to the Briganti nomograms) scheduled for radical prostatectomy and extended lymph node dissection (e-LND)
as gold standard.
Radboudumc, Nijmegen (n=40)
Wesley Hospital, Brisbane (n=60)
Garvin Institute, Sydney (n=60)